Journal: Journal of Biomechanical Engineering

Article Title: A Novel Approach to Assess the In Situ Versus Ex Vivo Mechanical Behaviors of the Coronary Artery

doi: 10.1115/1.4035262

Figure Lengend Snippet: Representative portion of the experimental setup for measuring the pressure-diameter response of the coronary artery in the in situ and partially dissected configurations. Two pressure transducers, P1 and P2, are cannulated and secured between the coronary artery segment of interest. Pressure is provided by a syringe pump (not shown). The IVUS transducer is delivered into the arterial lumen through a one-way port (not shown) and rests in the middle of the dissected segment. A series of ligatures and vascular clips are used to stop outflow from peripheral branches. During testing, the heart is fully submerged in a DPBS bath maintained at physiological temperature (not shown).

Article Snippet: A semi-automated routine was developed to segment the lumen boundary using the IVUS DICOM images in matlab (MathWorks, Natick, MA).

Techniques: In Situ

Journal: Journal of Biomechanical Engineering

Article Title: A Novel Approach to Assess the In Situ Versus Ex Vivo Mechanical Behaviors of the Coronary Artery

doi: 10.1115/1.4035262

Figure Lengend Snippet: Comparison of the pressure-diameter response between the in situ (n = 5; solid line circle markers) and partially dissected (n = 5; dashed line square markers) configurations. A significant increase in diameter was observed in the dissected arteries for pressures between 20 and 60 mm Hg (*P < 0.05; error bars are mean ± SD). Note that diameter data are not available for less than 20 mm Hg due to the arterial wall collapsing around the IVUS transducer.

Article Snippet: A semi-automated routine was developed to segment the lumen boundary using the IVUS DICOM images in matlab (MathWorks, Natick, MA).

Techniques: Comparison, In Situ